downstream
adverb or adjective
down·stream
ˈdau̇n-ˈstrēm 
1
: in the direction of or nearer to the mouth of a stream
floating downstream
located two miles downstream
2
: in or toward the latter stages of a usually industrial process or the stages (such as marketing) after manufacture
improving profits downstream
downstream products
3
biochemistry
: toward the end of a series of cellular processes : following a linked molecular event occurring in a sequence
But by looking downstream of the tumor suppressors [genes] at the proteins they influence, drug developers hope to find good targets.—
Marcia Barinaga
Marcia BarinagaExamples of downstream in a Sentence
Recent Examples on the Web
Kering plans to continue its use of certifications for its sourcing downstream of key commodities such as wood and rubber, and to continue its efforts to promote regenerative agriculture practices in its supply chain.
—Rhonda Richford, WWD, 31 Oct. 2024
Additionally, Lululemon, which is under investigation by Canada’s Competition Bureau for greenwashing, was recorded not to have provided evidence for assessing impacts on nature and biodiversity up and downstream of the supply chain.
—Amy Nguyen, Forbes, 4 Oct. 2024
Much of what was the iconic village of Chimney Rock is now wreckage situated downstream in Lake Lure.
—Patrik Jonsson, The Christian Science Monitor, 11 Oct. 2024
The female occupant was rescued, but McCrary and his dog were swept downstream.
—Saleen Martin, USA TODAY, 8 Oct. 2024
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Rhonda Richford, WWD, 31 Oct. 2024
Additionally, Lululemon, which is under investigation by Canada’s Competition Bureau for greenwashing, was recorded not to have provided evidence for assessing impacts on nature and biodiversity up and downstream of the supply chain.
—Amy Nguyen, Forbes, 4 Oct. 2024
Much of what was the iconic village of Chimney Rock is now wreckage situated downstream in Lake Lure.
—Patrik Jonsson, The Christian Science Monitor, 11 Oct. 2024
The female occupant was rescued, but McCrary and his dog were swept downstream.
—Saleen Martin, USA TODAY, 8 Oct. 2024
See all Example Sentences for downstream
Dictionary Entries Near downstream
Cite this Entry
“Downstream.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/downstream. Accessed 1 Dec. 2024.
Copy CitationKids Definition
downstream
adverb or adjective
down·stream
ˈdau̇n-ˈstrēm
: in the direction a stream is flowing
Medical Definition
downstream
adverb or adjective
down·stream
ˌdau̇n-ˈstrēm
1
: in the same direction along a molecule of DNA or RNA as that in which transcription and translation take place and toward the end having a hydroxyl group attached to the position labeled 3′ in the terminal nucleotide
a nucleotide sequence located downstream from the regulatory gene
effects on the expression of downstream genes
compare upstream sense 1
2
: toward the end of a series of cellular processes : following a linked molecular event occurring in a sequence
But by looking downstream of the tumor suppressors [genes] at the proteins they influence, drug developers hope to find good targets.—Marcia Barinaga, Science
Marcia Barinaga, ScienceThe tyrosine kinase activity of phosphorylated EGFR [epidermal growth factor receptor] in cancer cells results in the phosphorylation of downstream proteins that incite cell proliferation, invasion, metastasis, and inhibition of apoptosis.—Jonathan E. Dowell and John D. Minna, The New England Journal of Medicine
Jonathan E. Dowell and John D. Minna, The New England Journal of MedicineLove words? Need even more definitions?
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