annealed; annealing; anneals
1
a
: to heat and then cool (a material, such as steel or glass) usually for softening and making less brittle
Each bar, with its intricate twists, bevels and turns, had to be shaped individually. This shaping made some parts of the bars brittle … . To restore their flexibility, all the bars had to be annealed by heating, and then rapidly cooling them.—
Ivars Peterson
Ivars Peterson
also
: to cool slowly usually in a furnace
b
: to cause two complementary strands of nucleic acid (such as DNA or RNA) to join by hydrogen bonding
During repair of DNA double-strand breaks, cells must accurately anneal broken strands …—Seiji N. Sugiman-Marangos et al.
Seiji N. Sugiman-Marangos et al.
also
: to induce the binding of a genetic primer (see primer entry 2 sense 3) to a complementary single-stranded nucleic acid by slowly cooling single strands obtained from the heating and separation of double-stranded DNA or RNA
The primers are annealed to the single strands when the local temperature is reduced to between 50 and 65 C. —Andrew J. DeMello
Andrew J. DeMello During PCR, fragments are heated so they will separate into single strands. A short nucleotide sequence called a primer is then annealed to each original template. —George M. Church
George M. Church 2
1
: to pair with a complementary strand of nucleic acid
A microRNA molecule can anneal to a messenger RNA (mRNA) containing a nucleotide sequence that complements the sequence of the microRNA …—Carlo M. Croce
Carlo M. Croce
also
: to bind to a complementary single-stranded nucleic acid during a process of heating and cooling
Site-specific primers, designed to complement the base pairs of the DNA region flanking the target, anneal to these regions. —Norman Arnhelm and Corey H. Levenson
Norman Arnhelm and Corey H. Levenson 2
: strengthen, toughen
Mildred at least, is capable of love. In Veda, love has been annealed to a hard diamond of ambition.—Stephen King
Stephen King
Did you know?
Anneal Has a Fiery History
If you were looking for a saying to apply to the word anneal, it might be "everything old is new again." The word was originally associated with one of the oldest technologies of humankind: fire. It derives from the Old English word onǣlan, which was formed from the Old English root āl, meaning "fire." In its earliest known uses, anneal meant simply "to set on fire." That sense has become obsolete, however, and nowadays anneal is associated with metalworking and glasswork as well as a much more recent technological development. As addressed in sense 3 of the definition, it has come to be used in the context of DNA research, in reference to the heating and cooling of double-stranded nucleic acid.
Examples of anneal in a Sentence
Recent Examples on the Web
In this instance, after annealing, nanoplastic molecules are physically bound together with the molecules of tetracycline.
—Joe Salas, New Atlas, 3 Nov. 2024
Kaveh was certainly born a good person, but his overwhelming personal grace and the power of his art were annealed into their pure form by the white-hot fire of his addiction.
—Lauren Groff, TIME, 2 Oct. 2024
Bound wafers and chips are then heated slowly (a process called annealing) to form stronger chemical bonds.
—IEEE Spectrum, 4 June 2024
And researchers from Applied Materials presented progress on a method to radically reduce the time needed for annealing—from hours to just 5 minutes.
—IEEE Spectrum, 4 June 2024
For applications requiring a more pure silica glass, the residual organics can be removed by annealing the structures at 900° Celsius (1,652° F)—an extra step, granted, but at a much lower temperature than the usual extra sintering step.
—Jennifer Ouellette, Ars Technica, 7 July 2023
As expected, the researchers found that annealing the textiles at a temperature of 100 degrees Celsius improved their ability to generate electric charge.
—IEEE Spectrum, 10 Dec. 2023
While annealing the textiles was beneficial to both the aligned and random fiber distributions, the team was surprised by which orientation performed better overall.
—IEEE Spectrum, 10 Dec. 2023
The bread, annealed and shiny, was all crunch and butter.
—Jenn Harris, Los Angeles Times, 11 Sep. 2023
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Joe Salas, New Atlas, 3 Nov. 2024
Kaveh was certainly born a good person, but his overwhelming personal grace and the power of his art were annealed into their pure form by the white-hot fire of his addiction.
—Lauren Groff, TIME, 2 Oct. 2024
Bound wafers and chips are then heated slowly (a process called annealing) to form stronger chemical bonds.
—IEEE Spectrum, 4 June 2024
And researchers from Applied Materials presented progress on a method to radically reduce the time needed for annealing—from hours to just 5 minutes.
—IEEE Spectrum, 4 June 2024
For applications requiring a more pure silica glass, the residual organics can be removed by annealing the structures at 900° Celsius (1,652° F)—an extra step, granted, but at a much lower temperature than the usual extra sintering step.
—Jennifer Ouellette, Ars Technica, 7 July 2023
As expected, the researchers found that annealing the textiles at a temperature of 100 degrees Celsius improved their ability to generate electric charge.
—IEEE Spectrum, 10 Dec. 2023
While annealing the textiles was beneficial to both the aligned and random fiber distributions, the team was surprised by which orientation performed better overall.
—IEEE Spectrum, 10 Dec. 2023
The bread, annealed and shiny, was all crunch and butter.
—Jenn Harris, Los Angeles Times, 11 Sep. 2023
Dictionary Entries Near anneal
Cite this Entry
“Anneal.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/anneal. Accessed 28 Nov. 2024.
Copy CitationKids Definition
anneal
verb
an·neal
ə-ˈnē(ə)l 
: to heat and then cool so as to toughen and make less brittle
Medical Definition
anneal
transitive verb
an·neal
ə-ˈnē(ə)l
1
: to heat and then cool (as steel or glass) usually for softening and making less brittle
2
: to heat and then cool (double-stranded nucleic acid) in order to separate strands and induce combination at lower temperatures especially with complementary strands
: to be capable of combining with complementary nucleic acid by a process of heating and cooling
some bacterial nucleic acid anneals well with eukaryotic DNA
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